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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GLI3 All Species: 24.24
Human Site: S338 Identified Species: 59.26
UniProt: P10071 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0.11
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P10071 NP_000159.3 1580 169863 S338 S G S Y G H L S A S A I S P A
Chimpanzee Pan troglodytes Q5IS56 1580 169881 S338 S G S Y G H L S A S A I S P A
Rhesus Macaque Macaca mulatta XP_001098108 1580 169984 S338 S G S Y G H L S A S A I S P A
Dog Lupus familis XP_540363 1589 168926 S337 S G S Y G H L S A S A I S P A
Cat Felis silvestris
Mouse Mus musculus Q61602 1583 171637 S338 S G S Y G H L S A S A I S P A
Rat Rattus norvegicus
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506723 1591 170747 S338 S G S Y G H L S A S A I S P A
Chicken Gallus gallus P55879 663 73088
Frog Xenopus laevis Q91660 1569 172575 A341 S G S Y G H L A A S A I S P A
Zebra Danio Brachydanio rerio
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P19538 1397 153262 T310 F S I G H M P T S A S L R V N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34708 1110 122786 E122 A L G A S S D E L L Q P N A T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 98.6 86.4 N.A. 86.4 N.A. N.A. 79.4 29.1 68.8 N.A. N.A. 23 N.A. 20.5 N.A.
Protein Similarity: 100 99.8 99 90.1 N.A. 90.9 N.A. N.A. 86.2 34.8 79.8 N.A. N.A. 37.7 N.A. 35.1 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 N.A. N.A. 100 0 93.3 N.A. N.A. 0 N.A. 0 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 N.A. N.A. 100 0 100 N.A. N.A. 33.3 N.A. 13.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 0 0 10 0 0 0 10 70 10 70 0 0 10 70 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 10 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % E
% Phe: 10 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 70 10 10 70 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 10 70 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 10 0 0 0 0 0 0 0 0 70 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 0 10 0 0 0 0 70 0 10 10 0 10 0 0 0 % L
% Met: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 10 % N
% Pro: 0 0 0 0 0 0 10 0 0 0 0 10 0 70 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % R
% Ser: 70 10 70 0 10 10 0 60 10 70 10 0 70 0 0 % S
% Thr: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 10 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 10 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 70 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _